Table 3.

Association between statin use and risk and severity of acute kidney injury

CharacteristicPrehospital Statin UseNo Prehospital Statin UseP ValueContinued Statin UseNo Continued Statin UseP Value
Risk for AKI
 all patientsa (n=1836)176 (42.6)455 (32)<0.001144 (41.9)487 (32.6)0.001
 subgroup with cardiovascular diseaseb (n=467)86 (45.5)121 (43.5)0.6773 (44)134 (44.5)0.91
 subgroup without cardiovascular diseasec (n=1151)59 (37)275 (27.7)0.0146 (36.8)288 (28)0.04
Severity of AKId
 risk79 (45)228 (50.1)0.0168 (47.2)239 (49.1)0.02
 injury51 (29)84 (18.5)42 (29.2)93 (19.1)
 failure46 (26.1)143 (31.4)34 (23.6)155 (31.8)
  • Unless otherwise stated, data are number (percentage) of patients. AKI, acute kidney injury.

  • a Patients were classified as having developed AKI within the entire cohort of 1836 patients if they met any of the Risk, Injury, or Failure stages at any time during hospitalization as proposed by the Acute Dialysis Quality Initiative (25).

  • b Subgroup of 467 patients who had a history of pre-existing cardiovascular disease before hospitalization for community-acquired pneumonia (CAP).

  • c Subgroup of 1151 patients with no history of pre-existing cardiovascular disease before CAP hospitalization.

  • d For severity of AKI, 1836 patients within the entire cohort were classified according to the maximum Risk, Injury, or Failure reached during the entire hospitalization as proposed by the Acute Dialysis Quality Initiative (25).