Table 2.

Baseline characteristics of prehospital and continued statin use compared with no continued statin use

CharacteristicPrehospital and Continued Statin Usea (n=344)Prehospital but No Continued Statin Useb (n=69)P Value
Demographics
 mean age (yr)72.8±10.670.1±12.40.16
 male gender192 (55.8)35 (50.7)0.43
 white race315 (91.5)53 (76.8)0.001
 admitted from nursing home8 (2.3)4 (5.8)0.11
 Charlson Comorbidity Index
  mean score2.2±22±20.23
  patients with score > 0293 (85.1)51 (73.9)0.02
 CKD6 (1.7)3 (4.3)0.17
 cardiovascular disease166 (57)23 (39.6)0.01
 chronic respiratory disease137 (39.8)21 (30.4)0.14
 diabetes105 (30.5)20 (28.9)0.80
 cirrhosis115 (33.4)20 (28.9)0.43
 mean baseline creatinine (mg/dl)0.90±0.10.94±0.30.99
Healthy user indicators
 health insurance343 (99.7)67 (97.1)0.02
 lives at home322 (93.6)61 (88.4)0.12
 ambulating independently238 (69.1)41 (59.4)0.11
 previous smoker179 (52)25 (36.2)0.01
 current smoker51 (14.8)17 (24.6)0.12
 pneumococcal vaccine179 (52)30 (43.4)0.19
 influenza vaccine in the prior 8 months176 (51.1)31 (44.9)0.34
 long-term aspirin use192 (55.8)31 (44.9)0.09
 long-term anticoagulant use87 (25.2)16 (23.1)0.71
Severity of illness on day 1
 mean Pneumonia Severity Index score106.5±29.6105.1±33.60.89
 mean APACHE III score40.1±12.141.4±13.50.54
 mean SOFA score2.34±1.812.44±1.810.62
 severe sepsis42 (12.2)12 (17.4)0.24
Treatments administered
 antibiotic use in the last week59 (17.1)7 (10.1)0.14
 received antibiotics according to ATS guidelines281 (81.7)57 (82.6)0.85
  • Values expressed with a plus/minus sign are the mean ± SD. Unless otherwise noted, other values are number (percentage) of patients. APACHE, Acute Physiology and Chronic Health Evaluation; SOFA, Sequential Organ Failure Assessment; ATS, American Thoracic Society.

  • a Patients who were taking a statin medication as an outpatient in the 7 days before hospitalization for community-acquired pneumonia (CAP) and in whom the medication was continued during hospital stay.

  • b Patients who were taking a statin medication as an outpatient in the 7 days before CAP hospitalization and in whom the medication was not continued during hospital stay