Table 3.

Clinical and histopathologic characteristics of normotensive and hypertensive patients at biopsy

CharacteristicIgANORG
Normotensive (n=75)Hypertensive (n=23)P ValueNormotensive (n=7)Hypertensive (n=13)P Value
Clinical
 age (yr)31±1142±150.00334±1243±110.07
 men (%)39700.00957770.49
 BMI (kg/m2)21.2±2.523.7±3.30.00132.6±3.332.7±3.40.70
 estimated GFR (ml/min per 1.73 m2)90±1876±120.00188±2476±180.07
 urinary protein excretion (g/d)1.0±1.11.2±1.00.201.1±1.01.1±0.50.45
Histopathologic
 interstitial fibrosis/tubular atrophy (%)16±1124±150.00615±1316±100.64
 glomeruli affected by global glomerular sclerosis (%)12±1417±170.1511±1615±110.24
 glomeruli affected by segmental glomerular sclerosis (%)5.7±7.07.5±11.30.881.1±2.03.0±5.91.00
 patients with segmental glomerular sclerosis (%)51520.9029230.88
 GD1 (glomeruli/mm2)3.8±1.52.5±1.0<0.0011.6±0.81.7±0.50.70
 GD2 (glomeruli /mm2)4.2±1.62.9±1.00.0011.8±0.82.0±0.60.44
 GV (×106/μm3)2.6±1.03.8±1.0<0.0016.1±2.26.4±1.70.64
  • Values expressed with a plus/minus sign are the mean ± SD. IgAN, IgA nephropathy; ORG, obesity-related glomerulopathy; BMI, body mass index; GD, glomerular density (GD1: GD excluding global glomerular sclerosis; GD2: GD including global glomerular sclerosis); GV, glomerular volume.