Table 1.

Demographic features of SLE patients with renal vascular lesions compared with controls (n=161)

Controls (n=40)TMA (n=13)PLV (n=5)PUVID (n=10)PAS (n=93)P
Age at time of renal biopsy (year)33.1±8.935.1±12.20.5044.4±8.90.0139.1±10.50.0737.9±13.00.02
Female (n; %)35 (87.5)11 (84.6)1.005 (100.0)0.409 (90.0)0.8374 (79.6)0.28
Ethnicity (n; %)
 Caucasians22 (55.0)10 (76.9)3 (60.0)5 (50.0)59 (63.4)
 African Americans4 (10.0)2 (15.4)1 (20.0)2 (20.0)15 (16.1)
 SLEDAI at time of biopsy10.5±6.211.8±8.00.5720.8±7.70.00115.3±9.20.069.9±5.50.59
 SDI score ≥1 (n; %)5 (14.3)4 (57.1)0.034 (80.0)0.0012 (22.2)0.5635 (45.4)0.001
Medications in the year post biopsy
 cumulative steroid dose (g) median [IQR]7.6 [5.7, 42.9]23.2 [5.1, 66.1]0.395.0 [3.2, 7.2]0.1910.1 [6.0, 64.5]0.719.7 [4.4, 25.2]0.77
 immunosuppressive drugsa (n; %)23 (60.5)11(84.6)0.112 (50.0)0.684 (40.0)0.2452 (59.1)0.88
 antimalarial (n; %)21 (55.3)2(15.4)0.011 (25.0)0.256 (60.0)0.7945 (51.1)0.70
 ACE inhibitor or ARB (n; %)9 (23.7)7(53.8)0.082 (50.0)0.255 (50.0)0.1038 (43.2)0.04
 statins (n; %)2 (5.3)2 (15.4)0.270 (0.0)1.002 (20.0)0.1317 (19.3)0.04
 ASA (n; %)2 (5.3)1 (7.7)0.250 (0.0)1.002 (20.0)0.1310 (11.4)0.03
 coumadin (n; %)1 (2.6)2 (15.4)0.160 (0.0)1.000 (0.0)1.001 (1.1)0.51
  • Results are reported as mean (SD) or percentage or median and interquartile range. P<0.05 is considered a statistically significant difference. TMA, thrombotic microangiopathy on renal biopsy; LV, lupus vasculopathy on renal biopsy; UVID, uncomplicated vascular immune deposits on renal biopsy; AS, arterial sclerosis on renal biopsy; SLEDAI, SLE Disease Activity Index within 3 months of renal biopsy; SDI, Systemic Lupus International Collaborating Clinics Damage Index within 6 months of renal biopsy; IQR, interquartile range; ACE or ARB, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker; ASA, acetylsalicylic acid.

  • a Immunosuppressive drug use within 1 year of renal biopsy: azathioprine, mycophenolate mofetil, mycophenolate sodium, and cyclophosphamide (intravenous or oral).