Table 2.

Clinical and histopathologic findings in autopsy cases categorized by body mass index

CharacteristicsNonobese (n=25)Overweight (n=15)Obese (n=8)P Value
Clinical
 age (yr)66±1360±1157±130.05
 men (%)6067750.73
 BMI (kg/m2)19.8±3.028.2±1.033.9±4.2<0.001
 estimated GFR (ml/min per 1.73 m2)88±2589±3081±240.64
Histopathologic
 left kidney weight (g)149±30181±44213±790.01
 interstitial fibrosis/tubular atrophy (%)8±46±46±20.005
 glomeruli affected by global glomerular sclerosis (%)4.5±4.41.0±1.52.0±2.80.008
 GD1 (glomeruli/mm2)3.1±0.62.9±0.73.1±1.10.40
 GD2 (glomeruli/mm2)3.2±0.62.9±0.73.1±1.10.30
 GV (×106/μm3)2.4±0.73.8±1.53.7±1.5<0.001
  • Values expressed with a plus/minus sign are the mean ± SD. BMI, body mass index; GD, glomerular density (GD1: GD excluding global glomerular sclerosis; GD2: GD including global glomerular sclerosis); GV, glomerular volume.