Table 1.

Clinical and histopathologic characteristics at biopsy

CharacteristicsKidney Donors (n=20)Patients with IgAN (n=98)Patients with ORG (n=20)P Value
Donor versus ORGIgAN versus ORG
Clinical
 age (yr)59±934±1340±12<0.0010.04
 men (%)3545700.030.05
 BMI (kg/m2)23.5±3.421.8±2.932.7±3.3<0.001<0.001
 estimated GFR (ml/min per 1.73 m2)81±1887±1880±210.710.04
 patients with hypertension (%)2523650.004<0.001
 urinary protein excretion (g/d)NA1.1±1.11.1±0.7NA0.40
Histopathologic
 interstitial fibrosis/tubular atrophy (%)7±718±1216±110.0030.51
 glomeruli affected by global glomerular sclerosis (%)6±813±1514±130.020.52
 glomeruli affected by segmental glomerular sclerosis (%)06.2±8.22.4±4.90.280.03
 patients with segmental glomerular sclerosis (%)051250.040.03
 GD1 (glomeruli/mm2)3.1±1.03.5±1.51.7±0.6<0.001<0.001
 GD2 (glomeruli/mm2)3.3±1.13.9±1.61.9±0.7<0.001<0.001
 GV (×106/μm3)2.4±0.62.9±1.16.3±1.8<0.001<0.001
  • Values expressed with a plus/minus sign are the mean ± SD. IgAN, IgA nephropathy; ORG, obesity-related glomerulopathy; BMI, body mass index; GD, glomerular density (GD1: GD excluding global glomerular sclerosis; GD2: GD including global glomerular sclerosis); GV, glomerular volume.