Table 2.

Frequent Hemodialysis Network Daily Trial: Mean changes in physical measures and treatment comparison of changes for frequent (six times per week) versus conventional (three times per week) in-center hemodialysis

VariableNaTrtObserved Data (Mean ± SD)Unadjusted Treatment Comparison of Change to F12 (±SE)Adjusted Means and Treatment Effectsb (±SE or with 95% Confidence Intervals)
BaselineF4F12Month 4Month 12
Change from BaselineTreatment Comparison (6× versus 3×)Change from BaselineTreatment Comparison (6× versus 3×)
Short physical performance battery score818.2±2.68.1±3.27.9±2.80.25±0.30−0.21±0.210.05 (−0.50, 0.60)−0.41±0.210.21 (−0.34, 0.76)
968.6±2.68.5±2.88.4±2.8−0.16±0.19−0.20±0.19
Physical health composite (RAND-36)9038.4±9.436.6±9.538.6±9.53.3±1.3−1.8±0.73.4c (1.6, 5.3)0.4±0.82.9d (0.8, 5.1)
10038.7±11.040.6±10.942.1±10.81.7±0.73.4±0.8
Physical functioning (RAND-36)9061.0±24.756.3±26.159.1±24.76.5±3.3−3.8±2.14.5 (−1.1, 10.0)0.0±2.24.4 (−1.3, 10.2)
10258.6±27.060.1±29.664.0±27.70.7±2.04.5±2.1
  • Trt, treatment frequency; F4, month 4; F12, month 12; RAND-36, RAND 36-item health survey.

  • a For observed data, numbers are the randomized patients providing baseline and 4- and 12-month measurements. For adjusted results, all available data are used.

  • b Results of mixed effects analyses controlling for the baseline level of the factor analyzed, diabetes, age, and clinical center.

  • c P≤0.001.

  • d P≤0.01.