Table 3.

Distribution of responses to the four-item Morisky Medication Adherence Scale and aggregate adherence scores, as well as multivariable-adjusted prevalence ratios for medication adherence scores associated with the level of estimated GFR in the Reasons for Geographic and Racial Differences in Stroke study participants with a history of cardiovascular disease

Estimated GFR (ml/min per 1.73 m2)
≥60 (n=5545)45–59 (n=837)<45 (n=531)
Medication adherence scale items (percent answering yes)
 item 1: do you ever forget to take your medications?28.726.426.0
 item 2: are you ever careless in taking your medications?4.43.25.8
 item 3: do you ever miss taking your medications when you are feeling better?5.84.34.3
 item 4: do you ever miss taking any of your medications because you are feeling sick?4.43.15.3
Aggregate adherence scores (%)
 0 (best adherence)68.572.069.9
 123.421.522.8
 ≥2 (worst adherence)8.16.57.3
Prevalence ratios (95% confidence interval)
 1 versus 01.00 (ref)0.92 (0.80–1.06)0.99 (0.83–1.18)
 ≥2 versus 01.00 (ref)0.79 (0.60–1.03)0.81 (0.58–1.14)
  • Multivariable models include adjustment for age, sex, race, region of residence, marital status, education, income, current smoking, depression, cognitive impairment, diabetes mellitus, hypertension, and albuminuria. Cardiovascular disease is defined as prior myocardial infarction (by electrocardiogram or self-report), coronary revascularization (percutaneous coronary intervention or coronary artery bypass surgery), stroke, aortic aneurysm repair, lower extremity bypass surgery, or carotid endarterectomy or angioplasty.