Table 2.

Mean differences in annual rate of cognitive decline for an eGFR <60 ml/min per 1.73 m2 compared with an eGFR ≥60 ml/min per 1.73 m2

Age-Adjusted Only (95% CI)Multivariable Adjusteda (95% CI)
eGFR <60 ml/min per 1.73 m2 (CKD-EPI) (n=408)
 global cognitive score−0.003 (−0.02, 0.02)−0.002 (−0.02, 0.02)
 verbal memory composite score−0.003 (−0.03, 0.02)−0.002 (−0.02, 0.02)
 verbal fluency score−0.006 (−0.14, 0.13)0.002 (−0.14, 0.15)
 TICS score−0.06 (−0.14, 0.02)−0.05 (−0.14, 0.03)
eGFR < 60 ml/min per 1.73 m2 (cystatin C)b (n=665)
 global cognitive score0.004 (−0.02, 0.02)0.0005 (−0.02, 0.02)
 verbal memory composite score0.004 (−0.02, 0.03)−0.001 (−0.03, 0.02)
 verbal fluency score0.03 (−0.12, 0.17)0.01 (−0.004, 0.004)
 TICS score−0.03 (−0.12, 0.06)−0.02 (−0.11, 0.07)
eGFR < 60 ml/min per 1.73 m2 (PCr + cystatin C)b (n=329)
 global cognitive score−0.01 (−0.03, 0.008)−0.02 (−0.04, 0.01)
 verbal memory composite score−0.02 (−0.04, 0.01)−0.02 (−0.05, 0.01)
 verbal fluency score0.02 (−0.14, 0.18)−0.01 (−0.18, 0.16)
 TICS score−0.03 (−0.10, 0.04)−0.04 (−0.14, 0.05)
  • 95% CI, 95% confidence interval; eGFR, estimated GFR; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration equation; TICS, telephone interview for cognitive status; PCr, plasma creatinine.

  • a Adjusted for age, hypertension, body mass index, diabetes, cigarette smoking, cardiovascular disease, alcohol intake, physical activity (METs/wk), high cholesterol, participant education level, spouse’s education level, and postmenopausal hormone use.

  • b Cystatin C was measured in 1110 participants.