Table 2.

Piperacillin-tazobactam pharmacokinetics in 42 intensive care unit patients receiving continuous renal replacement therapy

Total DrugFree Drug
Piperacillin PK parameters
 protein binding (%)19.0±9.7
 Vd (L)34.5 (30.5)38.2 (26.5)
 Vd (L/kg)0.38 (0.20)0.43 (0.26)
 ke (h−1)0.104 (0.052)0.120 (0.073)
t1/2 (hours)9.6 (4.2)5.8 (3.6)
 clearance (ml/min)64.5 (59.7)78.6 (62.2)
 CRRT clearance (ml/min)27.6 (15.2)33.2 (14.9)
Tazobactam PK parameters
 protein binding (%)14.6 (36.5)
 Vd (L)38.1 (27.6)50.6 (54.1)
 Vd (L/kg)0.38 (0.33)0.50 (0.56)
 ke (h−1)0.086 (0.058)0.089 (0.063)
t1/2 (hours)11.5 (9.4)7.8 (6.3)
 clearance (ml/min)48.3 (46.5)83.6 (86.5)
 CRRT clearance (ml/min)25.7 (15.3)35.7 (17.8)
  • Data are presented as mean ± SD or median (intraquartile range). PK, pharmacokinetic; CRRT, continuous renal replacement therapy.