Table 3.

Cox proportional hazard model for the primary endpoint in IgA nephropathy patients with nephrotic syndrome (n=100)

UnadjustedAdjustedaAdjusteda
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Sex (male versus female)1.11 (0.49–2.54)0.791.94 (0.50–5.64)0.343.17 (0.76–13.13)0.12
Age (per 1 yr)0.99 (0.96–1.02)0.560.99 (0.96–1.03)0.400.98 (0.95–1.02)0.42
Diabetes mellitus (versus non-diabetes mellitus)1.10 (0.15–8.32)0.922.01 (0.18–22.66)0.571.03 (0.07–15.20)0.91
Baseline 24-h proteinuria (per 1 g/d)2.53 (1.07–5.99)0.030.94 (0.75–1.18)0.591.28 (0.98–1.72)0.07
Mean arterial pressure (per 1 mmHg)1.02 (0.99–1.04)0.221.02 (0.96–1.10)0.511.02 (0.95–1.10)0.62
SCr ≤1.2 mg/dl (versus >1.2 mg/dl)3.01 (1.32–6.87)0.015.78 (1.57–21.30)0.014.03 (1.05–15.46)0.04
Clinical responses
 complete remission1.00 (reference)1.00 (reference)1.00 (reference)
 partial remission7.24 (0.84–69.29)0.0714.49 (1.14–183.76)0.0410.57 (0.67–177.16)0.09
 no response or progression97.34 (12.22–775.31)<0.001215.97 (15.63–2983.60)<0.001369.48 (18.25–7495.96)<0.001
Haas classification
 class I + II1.00 (reference)1.00 (reference)
 class III1.74 (0.38–7.95)0.480.95 (0.16–5.34)0.95
 class IV2.23 (0.6–8.27)0.230.35 (0.06–2.01)0.23
 class V8.97 (2.16–37.17)0.011.10 (0.22–5.36)0.91
Oxford classification
 M1 (versus M0)1.95 (0.71–5.33)0.261.65 (0.48–6.46)0.44
 E1 (versus E0)0.79 (0.33–1.94)0.620.52 (0.15–1.68)0.32
 S1 (versus S0)1.15 (0.50–2.60)0.714.19 (0.93–18.86)0.06
 T1+T2 (versus T0)8.6 (2.29–30.90)0.0010.70 (0.09–5.56)0.69
  • All data are expressed as median (range). HR, hazard ratio; CI, confidence interval; SCr, serum creatinine; M, mesangial proliferation; E, endocapillary proliferation; S, segmental sclerosis; T, tubular atrophy/interstitial fibrosis; —, not applicable.

  • a Adjusted for sex, age, diabetes mellitus, baseline 24-hour proteinuria, mean arterial pressure, SCr, and pathologic findings.