Table 3.

Clinical predictors of piperacillin total drug pharmacokinetic parameters

Multivariate Linear RegressionParameter EstimateProbability>|t|
Volume of distribution Vd (adjusted R2=0.36)
 age (years)−0.54±0.230.02
 weight gain (kg)1.01±0.320.003
 current weight (kg)0.16±0.130.23
 CRRT filtera0.38
 catheter locationb0.80
Elimination constant Ke (adjusted R2=0.26)
 log(CRRT dose [ml/kg per minute])0.084±0.0280.005
 CRRT mode (CVVHD versus CVVHDF)0.0006±0.0120.60
 CCF score (n=36)−0.0035±0.00310.27
  • CRRT, continuous renal replacement therapy; CVVHD, continuous venovenous hemodialysis; CVVHDF, continuous venovenous hemodiafiltration; CCF, Cleveland Clinic, Cleveland, Ohio.

  • a NxStage Express versus Gambro M60/M100.

  • b Whether dialysis access and antibiotic infusion catheter were in the same vessel.