Table 2.

Hazard ratios and 95% confidence intervals for all-cause mortality, dialysis inception, and composite outcome for patients receiving sevelamer compared with patients receiving calcium carbonate

ModelHazard Ratio (95% Confidence Interval)
All-cause mortality
 unadjusted0.45 (0.23–0.91)
 adjusted for baseline covariates0.35 (0.16–0.76)
 adjusted for baseline covariates + TVC0.36 (0.15–0.83)
Dialysis inception
 unadjusted0.55 (0.35–0.88)
 adjusted for baseline covariates0.49 (0.29–0.81)
 adjusted for baseline covariates + TVC0.77 (0.45–1.34)
Composite end point (death, dialysis)
 unadjusted0.52 (0.35–0.76)
 adjusted for baseline covariates0.45 (0.29–0.70)
 adjusted for baseline covariates + TVC0.62 (0.40–0.97)
  • Baseline time invariant covariates were age, sex, diabetes, hypertension, basal creatinine clearance, and baseline coronary artery calcification (CAC) score. Time-varying covariates (TVC) were serum concentration of calcium, phosphorus, intact parathyroid hormone, cholesterol (total and LDL), triglycerides, C-reactive protein, creatinine clearance, systolic and diastolic BP, and CAC score. These variables were measured every 6 months during the follow-up. Covariates included in the final model were age, sex, diabetes, hypertension, basal and time-varying values of creatinine clearance, CAC score, calcium, intact parathyroid hormone, cholesterol, and C-reactive protein. (For more details, refer to the Materials and Methods.)