Table 2.

Analysis of patients who presented with nephrotic syndrome (n=100)

Complete RemissionPartial RemissionNo Response or Progression
Spontaneous RemissionImmunosuppressantAll
No. of patients, n (%)24 (24.0)24 (24.0)48 (48.0)32 (32.0)20 (20.0)
Age (yr)40.1±15.737.6±12.138.9±13.941.4±13.437.8±16.8
Male sex, n (%)12 (50.0)12 (50.0)24 (50.0)17 (53.1)10 (50.0)
Presenting symptoms, n (%)
 generalized edema23 (95.8)21 (87.5)44 (91.7)30 (93.7)19 (95.0)
 frothy urinea1 (4.2)3 (12.5)4 (8.3)2 (6.3)1 (5.0)
 gross hematuria00000
Hypertension, n (%)8 (33.3)4 (16.7)12 (25.0)4 (20.0)4 (20.0)
Diabetes mellitus, n (%)2 (8.3)0 (0.0)2 (4.2)1 (3.1)1 (5.0)
Systolic BP (mmHg)128.6±12.8132.21±19.73130.4±16.30131.1±15.2136.8±13.4
Diastolic BP (mmHg)80.3±11.780.5±10.280.4±10.982.6±10.182.9±8.9
Mean arterial pressure (mmHg)96.4±10.997.7±12.597.0±11.697.8±10.9100.7±9.2
Laboratory measurements
 baseline
  24-h proteinuria (g/d)5.3 (3.5–14.9)5.4 (3.5–15.9)5.4 (3.5–15.9)6.5 (3.6–16.0)5.5 (3.5–9.2)
  random UPCR (g/g)4.2 (3.5–6.7)5.9 (3.7–10.2)5.2 (3.5–10.2)6.0 (3.5–18.2)6.2 (3.5–11.2)
  SCr (mg/dl)1.1±0.31.1±0.41.1±0.41.2±0.31.3±0.4
  eGFR (ml/min per 1.73 m2)73.3±15.175.0±18.774.2±16.965.3±15.464.6±20.0
  serum albumin (g/dl)2.9±0.42.7±0.62.8±0.52.7±0.62.8±0.5
 last follow-up
  random UPCR (g/g)0.2 (0.01–2.2)0.2 (0.01–3.8)0.2 (0.01–3.8)1.6 (0.3–5.2)3.2 (1.3–10.2)
  SCr (mg/dl)1.1±0.61.0±0.51.1±0.52.2±0.96.1±1.8
  eGFR (ml/min per 1.73 m2)68.8±19.271.7±20.370.8±19.752.9±24.518.6±11.2
Type of immunosuppressants, n (%)
 none24 (100.0)024 (50.0)6 (18.8)5 (25.0)
 steroid only018 (75.0)18 (37.5)19 (59.3)8 (40.0)
 steroid + cyclosporin06 (25.0)6 (12.5)6 (18.8)4 (20.0)
 steroid + cyclophosphamide00001 (5.0)
 steroid + mycophenolate mofetil0001 (3.1)2 (10.0)
Duration of steroid (d)288 (162–902)316 (216–978)161 (102–405)
  • All data are expressed as mean ± SD or median (range). UPCR, urinary protein-to-creatinine ratio; SCr, serum creatinine; eGFR, estimated GFR; —, not applicable.

  • a The presenting symptoms were recorded at the first hospital visit. Generalized edema was not present initially in seven patients, but they had acute onset of NS during follow-up. In fact, they showed generalized edema when NS occurred.