Table 3.

Mean differences in annual rate of cognitive decline for an ACR ≥5 mg/g and ≥10 mg/g compared with lower levels

Age-Adjusted Only (95% CI)Multivariable Adjusteda (95% CI)
ACR ≥5 mg/g (n=440)
 global cognitive score−0.03 (−0.05, −0.01)−0.03 (−0.05, −0.01)
 verbal memory composite score−0.03 (−0.05, −0.004)−0.02 (−0.05, −0.001)
 verbal fluency score−0.18 (−0.31, −0.04)−0.19 (−0.34, −0.05)
 TICS score−0.09 (−0.16, −0.009)−0.09 (−0.17, −0.004)
ACR ≥10 mg/g (n=228)
 global cognitive score−0.03 (−0.05, −0.009)−0.04 (−0.06, −0.01)
 verbal memory composite score−0.02 (−0.05, 0.005)−0.02 (−0.05, 0.01)
 verbal fluency score−0.16 (−0.33, 0.02)−0.19 (−0.38, −0.01)
 TICS score−0.13 (−0.23, −0.03)−0.13 (−0.24, −0.02)
  • 95% CI, 95% confidence interval; ACR, urinary albumin/creatinine ratio; TICS, telephone interview for cognitive status.

  • a Adjusted for age, hypertension, body mass index, diabetes, cigarette smoking, cardiovascular disease, alcohol intake, physical activity (METS/wk), high cholesterol, participant education level, spouse’s education level, and postmenopausal hormone use.