Table 4.

Cox proportional hazard model for prediction of spontaneous remission of nephrotic syndrome in patients with IgA nephropathy (n=100)

UnadjustedAdjustedaAdjusteda
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Sex (female versus male)1.37 (0.62–3.04)0.443.81 (1.39–10.45)0.0093.45 (1.17–10.15)0.02
Age (per 1 yr)1.01 (0.98–1.03)0.791.01 (0.97–1.02)0.691.01 (0.97–1.05)0.52
Mean arterial pressure (per 1 mmHg)0.98 (0.95–1.02)0.380.99 (0.95–1.02)0.470.99 (0.96–1.04)0.88
Baseline 24-h proteinuria (per 1 g/d)0.92 (0.78–1.09)0.321.10 (0.87–1.35)0.441.12 (0.92–1.37)0.27
Proteinuria decrease >50% within 3 mo6.16 (2.72–13.96)<0.0018.37 (3.12–22.40)<0.0019.71 (3.51–26.87)<0.001
SCr ≤1.2 mg/dl (versus >1.2 mg/dl)3.50 (1.04–11.75)0.044.85 (1.21–19.39)0.024.20 (1.05–16.76)0.04
Haas classification
 class I + II1.22 (0.36–4.17)0.691.10 (0.24–4.66)0.92
 class III0.84 (0.24–2.97)0.740.76 (0.17–3.39)0.72
 class IV0.65 (0.19–2.23)0.421.10 (0.27–4.13)0.92
 class V1.00 (reference)1.00 (reference)
Oxford classification
 M1 (versus M0)0.54 (0.24–1.22)0.141.98 (0.66–5.98)0.18
 E1 (versus E0)1.30 (0.56–2.97)0.530.76 (0.27–2.12)0.61
 S1 (versus S0)1.66 (0.72–3.78)0.231.11 (0.40–3.04)0.81
 T1+T2 (versus T0)0.44 (0.10–1.88)0.172.42 (0.44–12.38)0.26
  • All data are expressed as median (range). HR, hazard ratio; CI, confidence interval; SCr, serum creatinine; M, mesangial proliferation; E, endocapillary proliferation; S, segmental sclerosis; T, tubular atrophy/interstitial fibrosis; —, not applicable.

  • a Adjusted for sex, age, mean arterial pressure, baseline 24-hour proteinuria, a >50% decrease in proteinuria within 3 months, SCr, and pathologic findings.