Table 1.

Baseline characteristics and laboratory values of all subjects

ParametersKT (n=229)Normal (n=46)CKD (n=202)
Age (year)48.9±11.745.5±9.254.5±11.5
Male sex (n/%)149 (65)22 (47.8)128 (63.4)
Body weight (kg)63±12.162.8±19.568.5±14.7
DM (n/%)58 (25.3)104 (51.5)
Cadaveric KT (n/%)109 (48)
Duration of KT (yr)a5.7 (2.4–10)
Active vitamin D (n/%)21 (9.2)6 (3)
Nutritional vitamin D (n/%)0 (0)19 (9.4)
Calcium supplement (n/%)56 (12)47 (23.3)
Immunosuppressive drugs
 corticosteroid (n/%)229 (100)
 calcineurin inhibitor (n/%)201 (88)
 mTOR inhibitor (n/%)31 (13)
Laboratory values
 calcium (mg/dl)b9.6±0.79±0.49.3±0.5
 phosphate (mg/dl)3.3±0.63.8±0.53.7±0.6
 albumin (g/l)40.5±4.542.6±2.937.9±5.6
 PTH (pg/ml)a75 (54–110)36 (29–42)60 (39–84)
 FGF-23 (RU/ml)a19 (11–29)18 (14–24)
 25-OH-D (ng/dl)26.1±8.622.1±8.7
 1-25-OH-D (pg/ml)c48.5±25.5
 24-hour urine Pi (g/day)0.53±0.20.45±0.2
 FePi (%)22.3±108.2±3.2
 TmP/GFR (mg/dl)2.6±0.63.5±0.5
 eGFR (ml/min per 1.73 m2)d55.7±19.399.4±22.343.5±16.3
CKD stages (n/%)
 stages 1 and 2100 (43.7)30 (14.9)
 stage 3 106 (46.3)126 (62.3)
 stages 4 and 523 (10)46 (22.8)
  • KT, kidney transplantation; DM, diabetes mellitus; mTOR, target of rapamycin; PTH, parathyroid hormone; FGF-23, fibroblast growth factor 23; 25-OH-D, 25-hydroxyvitamin D; 1,25-OH-D, 1,25-dihydroxyvitamin D; FePi, fractional excretion of phosphate; TmP/GFR; tubular maximum phosphate reabsorption/GFR.

  • a Median (interquartile range).

  • b Corrected calcium.

  • c n=126 (Materials and Methods).

  • d Calculated by the Modification of Diet in Renal Disease formula.