Table 2.

Primary event rates according to CHADS2 score and CKD status in participants not assigned to adjusted-dose warfarina

Risk GroupeGFR >60 ml min per 1.73 m2Stage 3 CKD eGFR 30 to 59 ml/min per 1.73 m2
nNo. of Events2-year Rate (%)nNo. of Events2-year Rate (%)
All participants859284.1538369.2b
CHADS2 = 027531.58934.6
CHADS2 = 130683.316853.8
CHADS2 = 216164.31401314.1
CHADS2 = 375711.47746.7
CHADS2 ≥ 442415.2641124.9
  • a SPAF III participants assigned to aspirin or to aspirin plus fixed, low-dose warfarin (see Materials and Methods); 16 patients with stage 4 chronic kidney disease (CKD) were excluded; were 96% of primary events were ischemic strokes. For the CHADS2 score, one point is given for each of Congestive heart failure, Hypertension, Age ≥75, and Diabetes mellitus, and 2 points for prior Stroke/transient ischemic attack.(18)

  • b P = 0.004 compared with those with estimated GFR (GFR) ≥60 ml/min per 1.73 m2; 95% confidence intervals for the rates are shown in Figure 2.