Table 3.

Association between clinical measurements and percentage difference in serum osteoprotegerin levels

Percentage Difference (95% CI)P
Chronic Kidney Disease-Mineral and Bone Disorder measuresa
    serum phosphate (per 1 mg/dl)6.5% (−1.5%, 15%)0.11
    corrected serum calcium (per 1 mg/dl)−1.7% (−11.2%, 8.8%)0.74
    calcium X phosphorus product0.2% (−0.6%, 1.0%)0.58
    intact PTH ≥66 pg/ml3.4% (−6.1%, 13.9%)0.49
    intact PTH above KDOQI guidelines5.4% (−4.8%, 16.6%)0.31
    total alkaline phosphatase (per 10 U/L)1.5% (0%, 3.1%)0.05
    bone-specific alkaline phosphatase (per 10 U/L)−1.5% (−4.5%, 1.5%)0.32
    cortical bone mineral content (per 50 g)1.6% (−2.5%, 5.9%)0.45
Demographics and vascular risk factorsb
    age (per 10 years)7.1% (2.6%, 11.8%)<0.01
    female gender10.2% (0.2%, 21.3%)0.05
    black race1.0% (−7.7%, 10.5%)0.83
    diabetes8.1% (−0.8%, 17.8%)0.08
    cardiovascular disease9.3% (−0.1%, 19.6%)0.05
    hypertension5.2% (−8.2%, 20.5%)0.46
    current/former smoker4.3% (−4.5%, 14.0%)0.35
    systolic BP (per 10 mmHg)2.7% (0.6%, 4.9%)0.01
    eGFR (per 10 ml/min per 1.73 m2)−3.9% (−6.8%, −0.8%)0.01
    serum albumin (per 1 mg/dl)−17.0% (−25.8%, −7.2%)<0.01
  • PTH, parathyroid hormone; KDOQI, Kidney Disease Outcomes Quality Initiative; eGFR, estimated GFR.

  • a Percentage difference values were adjusted for age, gender, and race.

  • b Percentage difference values were adjusted for all other demographics and vascular risk factors.