Table 3.

Comparison of baseline clinical features between different pathologic lesions of Oxford Classification in 410 enrolled patients, and compared to the original Oxford study

Pathologic lesionPresent StudyOxford Study(8)
N (%)MAP mmHgPeGFR ml/min per 1.73 m2PUrine Protein g/dayPMAP mmHgPeGFR ml/min per 1.73 m2PU-pro g/dayP
Mesangial hypercellularity score ≤0.54494.8 ± 13.00.8290.1 ± 25.70.011.5 (0.5 to 18.8)0.69100>0.184>0.11.40.01
Mesangial hypercellularity score >0.55693.1 ± 15.081.7 ± 28.71.7 (0.5 to 21.8)98822.0
No endocapillary hypercellularitya4393.4 ± 14.30.5386.6 ± 28.40.891.8 (0.5 to 18.8)0.941010.08760.011.50.01
Any endocapillary hypercellularity5794.6 ± 14.185.2 ± 27.31.7 (0.5 to 21.8)95922.0
Endocapillary hypercellularity ≤25%8393.0 ± 15.0<0.0188.9 ± 27.5<0.011.6 (0.5 to 18.9)0.01
Endocapillary hypercellularity >25%1799.2 ± 14.170.5 ± 17.52.4 (0.5 to 21.8)
No extracapillary proliferation3993.4 ± 14.90.8191.1 ± 28.00.031.7 (0.5 to 18.9)0.2098>0.184>0.11.50.02
Any extracapillary proliferation6194.6 ± 13.782.4 ± 27.21.8 (0.5 to 21.8)98802.2
Extracapillary glomerular activity indexb<48094.3 ± 14.40.8487.3 ± 27.80.061.7 (0.5 to 21.8)0.79
Extracapillary glomerular activity index ≥42092.6 ± 13.177.9 ± 26.81.8 (0.5 to 15.7)
No segmental glomerulosclerosis2594.0 ± 12.80.7692.5 ± 29.40.051.8 (0.5 to 21.8)0.58940.04950.031.50.04
Any segmental glomerulosclerosis7594.1 ± 14.683.5 ± 26.81.7 (0.5 to 15.7)100791.9
Tubular atrophy and interstitial fibrosis
    mild (0 to 25%)7892.6 ± 13.2<0.0192.9 ± 24.1<0.011.5 (0.5 to 21.8)0.04990.0386<0.011.70.03
    moderate (26 to 50%)14100.3 ± 17.965.2 ± 26.62.3 (0.7 to 13.7)100591.8
    severe (51%+)8100.3 ± 10.353.2 ± 27.82.4 (0.5 to 15.7)105463.0
Artery score
    mild9193.9 ± 14.30.8987.1 ± 27.40.061.7 (0.5 to 21.80.731040.0267<0.011.5>0.1
    moderate696.0 ± 13.474.1 ± 26.42.0 (0.6 to 8.3)101701.6
    severe395.8 ± 10.265.9 ± 34.52.3 (0.5 to 8.2)102721.7
  • eGFR, estimated GFR; demonstrated as mean ml/min per 1.73 m2. MAP, mean arterial pressure, demonstrated as mean mmHg. Proteinuria, demonstrated as median g/day.

  • a Endocapillary hypercellularity involving no more than or more than 25% glomeruli defined as endocapillary hypercellularity ≤25% or >25%.

  • b Extracapillary glomerular activity index was defined to evaluate the severity of crescent, which was scored by a double weight of >50% circumferential cellular or fibrocellular crescents.