Table 3.

Associations between serum bicarbonate levels and all-cause mortality among chronic kidney disease patients

Bicarbonate GroupUnadjusted HR [95% CI] (n = 41,445)Model A HR [95 %CI] (n = 41,445)Model B HR [95 %CI] (n = 37,687)Model C HR [95% CI] (n = 37,687)
<23 mmol/L versus 23 to 32 mmol/L1.65 (1.56, 1.75)1.75 (1.65, 1.85)1.35 (1.27, 1.44)1.23 (1.16, 1.31)
>32 mmol/L versus 23 to 32 mmol/L2.12 (1.86, 2.42)2.08 (1.83, 2.37)1.76 (1.54, 2.02)1.74 (1.52, 2.00)
  • Model A adjusted for age, gender, and race. Model B adjusted variables included in Model A, plus body mass index, diabetes, hypertension, hyperlipidemia, malignancy, congestive heart failure, cerebrovascular disease, coronary artery disease, chronic obstructive pulmonary disease, history of angiotensin-converting enzyme/angiotensin receptor blocker prescription, history of diuretic prescription at chronic kidney disease diagnosis, and hemoglobin and albumin. Model C adjusted variables included in Model B, plus baseline estimated GFR. HR, hazard ratio; CI, confidence interval.