Table 4.

Age-stratified hazard ratios of all-cause mortality associated with level of albuminuria for REGARDS study participants with (top panel) and without (bottom panel) diabetes mellitus

Age Group, Years
45 to 59.960 to 69.970 to 79.9≥80
Participants with diabetes mellitus
    albuminuria, mg/g
        <101 (ref)1 (ref)1 (ref)1 (ref)
        10 to 29.91.4 (0.6 to 3.48)1.1 (0.8 to 1.7)1.4 (0.96 to 2.0)2.2 (1.1 to 4.4)
        30 to 299.92.4 (1.00 to 5.8)1.8 (1.2 to 2.6)1.7 (1.2 to 2.5)1.6 (0.8 to 3.2)
        ≥3003.3 (1.1 to 10.3)2.2 (1.3 to 3.9)3.1 (1.9 to 5.2)4.0 (1.4 to 11.3)
    P trend0.01<0.01<0.01<0.01
Participants without diabetes mellitus
    albuminuria, mg/g1 (ref)1 (ref)1 (ref)1 (ref)
        <101.4 (0.9 to 2.1)1.4 (1.05 to 1.8)1.4 (1.1 to 1.7)1.7 (1.3 to 2.3)
        10 to 29.91.4 (0.8 to 2.4)1.9 (1.4 to 2.7)1.5 (1.1 to 1.9)2.3 (1.7 to 3.1)
        30 to 299.93.3 (1.1 to 9.6)2.1 (1.1 to 3.8)2.2 (1.3 to 3.7)4.8 (2.8 to 8.4)
        ≥3000.06<0.01<0.01<0.01
  • Data presented as multivariable adjusted HR (95% CI). Multivariable adjusted includes age, gender, race, region, education, physical activity, income, current smoking, general health status, waist circumstance, systolic BP, diastolic BP, antihypertensive medicine use, LDL cholesterol, HDL cholesterol, statin use, C-reactive protein ≥ 2 mg/L, history of coronary heart disease, self-reported stroke, self-reported or electrocardiogram evidence of atrial fibrillation, and estimated GFR. HR, hazard ratio.