Table 5.

Fluid and electrolyte case 2: clinical cases in which proximal tubular dysfunction developed in association with acute ingestion of large quantities of a nonsteroidal anti-inflammatory drug

Case (reference)SubstanceClinical FeaturesOutcome
28-year-old woman (8)40 to 60 tablets Nurofen PlusFanconi syndrome, K+ 1.4, ↓ PO4Reversible
49-year-old man (9)30 tablets Nurofen PlusFanconi syndrome, K+ 2.0, ↓ PO4Reversible
45-year-old woman (10)“Large quantity” Nurofen PlusFanconi syndrome, K+ 2.6, ↓ PO4Reversible
17-year-old woman (12)25 tablets acetylsalicylateFanconi syndromeReversible
Single case (age and sex not reported) (13)“Acute salicylate intoxication”AminoaciduriaReversible
  • Nurofen Plus (ibuprofen 200 mg, codeine phosphate 12.8 mg); K+ (mEq/L).