Table 4.

Histopathologic features of Oxford Classification of IgA nephropathy as predictors of ESRD in 410 patients by Cox regression model

ESRD Risk
Univariate Hazard Ratioa (95%CI)Multivariate Hazard Ratiob (95%CI)
Mesangial hypercellularity score
    ≤0.5referencereference
    >0.54.82 (2.03 to 11.47)1.85 (0.66 to 5.22)
P<0.001P = 0.12
Segmental glomerulosclerosis
    absentreferencereference
    present7.51 (1.78 to 31.77)5.22 (1.14 to 23.94)
P = 0.001P = 0.03
Tubular atrophy/interstitial fibrosis
    0 to 25%referencereference
    26 to 50%9.50 (3.69 to 24.44)4.78 (1.41 to 16.20)
    >50%31.97 (11.99 to 85.21)11.02 (2.99 to 40.64)
P<0.001P<0.001
Extracapillary hypercellularity
    absentreferencereference
    present3.60 (1.38 to 9.41)1.85 (0.70 to 4.88)
P = 0.0090.22
Extracapillary glomerular activity index
    <4reference
    ≥41.60 (0.73 to 3.52)
0.24
Endocapillary hypercellularity
    ≤25% presentreference
    >25% present1.28 (0.54 to 3.02)
0.57
  • CI, confidence interval; ESRD, end stage renal disease defined as estimated GFR <15 ml/min per 1.73 m2 or received renal replacement therapy. Extracapillary glomerular activity index and was defined to evaluate the severity of crescent, which was scored by a double weight of >50% circumferential cellular or fibrocellular crescent.

  • a Endocapillary and arterial lesions were not associated with ESRD in univariate analysis.

  • b Multivariate Model: histopathologic features, including mesangial hypercellularity, segmental glomerulosclerosis, endocapillary hypercellularity, extracapillary hypercellularity and tubular atrophy/interstitial fibrosis, and clinical features, including initial eGFR, MAP, and proteinuria and treatment were in the model.