Table 2.

Change of study parameters after treatment

SevelamerCalcium acetate
BasalFinalP valueBasalFinalP value
Calcium (mg/dl)9.0 ± 0.79.1 ± 0.50.339.0 ± 0.59.3 ± 0.5<0.01
Phosphate (mg/dl)5.4 ± 1.04.9 ± 1.0<0.0015.1 ± 0.64.7 ± 0.7<0.001
Ca x P (mg2/dl2)49.9 ± 13.045.3 ± 11.7<0.00146.5 ± 6.444.5 ± 7.8<0.001
Intact PTH (pg/ml)247 ± 92196 ± 94<0.001258 ± 145217 ± 136<0.001
C-reactive protein (mg/L)6.9 (5.9 to 8)5.9 (5.1 to 10)0.015.9 (4.7 to 6)5.4 (4 to 7.1)0.45
TNF-α (pg/ml)8 (6 to 8.4)7.1 (5.9 to 7.6)0.586.4 (5.8 to 8.7)7 (6.1 to 8.1)0.26
Interleukin-1 (pg/ml)0.8 (0.5 to 1.2)0.8 (0.51 to 1.0)0.561.2 (0.8 to 1.4)1.1 (0.9 to 1.2)0.92
Interleukin-6 (pg/ml)5 (3 to 9.1)4.9 (2.68 to 8.6)0.0014.9 (4 to 8.1)4.8 (4.2 to 7.8)0.03
Interleukin-10 (pg/ml)75 (52 to 98)71 (69 to 96)0.05977 (71 to 94)80 (65 to 96)0.64
Interleukin-18 (pg/ml)599 (514 to 635)601 (499 to 658)0.74526 (420 to 621)574 (428 to 620)0.34
Endotoxin (EU/ml)0.58 (0.51 to 0.60)0.42 (0.27 to 0.54)0.0010.60 (0.51 to 0.63)0.60 (0.48 to 0.69)0.57
Soluble CD14 (μg/ml)2.94 (1.76 to 5.29)2.57 (1.36 to 4.52)0.0012.88 (2.35 to 4.70)2.56 (2.21 to 0.98)0.93
  • Values are means ± SDs or median and interquartile range in parentheses. PTH, parathyroid hormone.