Table 5.

Age-stratified HR for all-cause mortality associated with level of albuminuria and eGFR

eGFR, ml/min per 1.73 m2P Trend
≥60 years45 to 59.9 years<45 years
Age 45 to 59.9 years
    ACR, mg/g
        <101 (ref)4.5 (1.8 to 11.1)4.7 (0.7 to 34.2)<0.01
        10 to 29.91.8 (1.2 to 2.7)1.8 (0.3 to 13.0)NA0.91
        30 to 299.92.3 (1.5 to 3.7)8.4 (2.6 to 26.5)9.7 (3.0 to 30.9)<0.01
        ≥3004.7 (2.2 to 9.7)10.5 (3.3 to 33.5)14.2 (7.3 to 27.7)0.02
    P trend<0.010.180.18
Age 60 to 69.9 years
    ACR, mg/g
        <101 (ref)1.9 (1.2 to 3.1)2.5 (1.0 to 6.1)<0.01
        10 to 29.91.5 (1.2 to 1.9)3.5 (2.1 to 5.9)4.6 (2.1 to 10.5)<0.01
        30 to 299.92.6 (2.0 to 3.3)4.5 (2.7 to 7.3)5.9 (3.3 to 10.5)<0.01
        ≥3004.0 (2.5 to 6.3)6.1 (3.1 to 11.9)9.8 (6.4 to 15.1)<0.01
    P trend<0.01<0.01<0.01
Age 70 to 79.9 years
    ACR, mg/g
        <101 (ref)1.1 (0.8 to 1.6)2.1 (1.2 to 3.6)0.03
        10 to 29.91.5 (1.3 to 1.9)1.8 (1.3 to 2.7)4.3 (2.8 to 6.4)<0.01
        30 to 299.92.1 (1.6 to 2.6)2.5 (1.7 to 3.6)5.0 (3.6 to 7.2)<0.01
        ≥3003.8 (2.5 to 5.6)5.6 (3.3 to 9.4)5.8 (3.9 to 8.9)0.12
    P trend<0.01<0.010.02
Age ≥ 80 years
    ACR, mg/g
        <101 (ref)1.4 (0.9 to 2.2)1.6 (0.9 to 2.8)0.04
        10 to 29.91.6 (1.2 to 2.3)2.3 (1.5 to 3.5)2.2 (1.2 to 3.7)0.05
        30 to 299.91.9 (1.3 to 2.7)3.0 (2.0 to 4.5)5.2 (3.5 to 7.6)<0.01
        ≥3006.2 (3.5 to 10.9)5.7 (3.1 to 10.6)4.9 (2.7 to 8.9)0.74
    P trend<0.01<0.01<0.01
  • P interaction between ACR and eGFR > 0.1 for each age group. HRs are adjusted for age, race, gender, and geographic region of residence. HR, hazard ratio; eGFR, estimated GFR; ACR, albumin-to-creatinine ratio; ref, reference NA, only five participants in this cell with zero deaths.