Table 4.

Age-corrected HR-pQCT and DXA results in women and men with and without a history of fracture

HR-pQCTWomenMenP
No Fracture (n = 18)Fracture (n = 16)Percent Difference (95% CI)No Fracture (n = 32)Fracture (n = 8)Percent Difference (95% CI)
MeanSDMeanSDMeanSDMeanSD
HR-pQCT tibia
    Dtot (mg HA/cm3)2541517815−30 (−26 to −34)2461022222−10 (−6 to −14)<0.01
    Dcort (mg HA/cm3)8121973920−10 (−7 to −11)7921376928−3 (−1 to −5)<0.05
    CtTh (mm)0.9290.0550.6420.081−31 (−26 to −37)0.9930.0550.8160.114−18 (−12 to −23)<0.01
    Dtrab (mg HA/cm3)147109510−35 (−31 to −40)1477.3512315−16 (−11 to −21)<0.01
    BV/TV (%)12.30.98.20.9−33 (−28 to −38)12.30.610.51.3−15 (−10 to −20)<0.01
    TbN (mm−1)1.670.1041.240.1−25 (−22 to −30)1.840.0741.670.153−9 (−5 to −13)<0.05
    TbTh (mm)0.0740.0040.0710.005−4 (0 to −14)0.0670.0030.0630.007−6 (0 to −14)0.55
    Tb1/NSD (mm)0.2860.0620.6410.065124 (107 to 138)0.2370.0440.3110.09231 (13 to 50)<0.01
HR-pQCT radius
    Dtot (mg HA/cm3)2931421721−26 (−22 to −30)2691426129−3 (2 to −8)0.09
    Dcort (mg HA/cm3)8262276024−8 (−6 to −10)78416799332 (0 to −4)0.35
    CtTh (mm)0.7210.0640.4790.067−34 (−28 to −40)0.6550.0450.6080.093−7 (0 to −14)0.06
    Dtrab (mg HA/cm3)134129612−28 (−22 to −35)145813317−8 (−3 to −14)0.08
    BV/TV (%)11.318.21.1−27 (−21 to −34)12.30.711.11.5−10 (−4 to −16)0.08
    TbN (mm−1)1.710.1091.350.115−21 (−16 to −26)1.900.0781.600.161−16 (−12 to −20)<0.01
    TbTh (mm)0.0630.0040.0590.004−6 (−4 to −17)0.0630.0030.0590.005−6 (0 to −17)0.30
    Tb1/NSD (mm)0.2460.0440.4590.04687 (72 to 96)0.250.0310.2820.06413 (0 to 24)<0.05
DXA
    lumbar spine (g/cm2)1.000.060.780.059−22 (−18 to −26)0.950.0460.890.079−6 (−2 to −11)0.09
    femoral neck (g/cm2)0.670.0440.560.043−17 (−12 to −21)0.680.0330.600.058−11 (−7 to −16)0.05
    radius (g/cm2)0.480.030.360.029−24 (−21 to −29)0.530.0230.510.039−4 (0 to −8)0.06
  • P values <0.05 indicate statistically significant differences between patients with and without fractures (main effect of a two-way analysis of covariance; fracture and gender as subject factors, age as covariate). HR-pQCT, high-resolution peripheral quantitative computed tomography; DXA, dual-energy x-ray absorptiometry; CI, confidence interval; Dtot, total density; HA, hydroxyapatite; Dcort, cortical density; CtTh, cortical thickness; Dtrab, trabecular thickness; BV/TV, trabecular bone volume; TbN, trabecular number; TbTh, trabecular thickness; Tb1/NSD, SD of 1/TbN.