Table 2.

Area under the receiver-operating characteristic curve at each time point for urinary biomarkers and urine output for predicting renal recovery

Urinary BiomarkersTime after EnrollmentAUC95% CI
uNGALDay 10.580.45 to 0.71
Day 70.560.40 to 0.72
Day 140.660.44 to 0.88
Largest relative changea0.700.55 to 0.84
uHGFDay 10.510.37 to 0.64
Day 70.700.55 to 0.84
Day 140.740.53 to 0.94
Largest relative changea0.740.60 to 0.89
uCystatin CDay 10.660.53 to 0.78
Day 70.400.24 to 0.57
Day 140.460.22 to 0.70
Largest relative changea0.610.46 to 0.77
uIL-18Day 10.540.41 to 0.67
Day 70.520.36 to 0.69
Day 140.480.24 to 0.72
Largest relative changea0.420.26 to 0.58
uNGAL/MMP-9Day 10.480.35 to 0.62
Day 70.530.37 to 0.70
Day 140.450.21 to 0.69
Largest relative changea0.530.37 to 0.69
uCreatinineDay 10.620.50 to 0.75
Day 70.550.39 to 0.71
Day 140.480.23 to 0.74
Largest relative changea0.660.51 to 0.81
Urine output >1 L/dDay 10.550.48 to 0.62
Day 70.590.48 to 0.69
Day 140.600.47 to 0.73
  • AUC, area under the receiver-operating characteristic curve; CI, confidence interval; uNGAL, urinary neutrophil gelatinase-associated lipocalin; uHGF, urinary hepatocyte growth factor; uCystatin C, urinary cystatin C; uIL-18, urinary IL-18; MMP-9, matrix metalloproteinase protein-9; uCreatinine, urinary creatinine.

  • a Largest relative change in the first 14 days as compared with day 1.