Table 3b.

Logistic regression analysis with variables available for predicting renal recovery and model accuracy after combining variables: Biomarkers model alone

ModelAUC (95% CI)Pb
Day 1
    uCystatin C0.66 (0.53 to 0.78)NA
    uCystatin C + uNGAL0.68 (0.56 to 0.80)0.32
    uCystatin C + uNGAL + uIL-180.73 (0.62 to 0.85)0.26
    uCystatin C + uNGAL + uIL-18 + uHGF0.73 (0.62 to 0.85)0.26
    uCystatin C + uNGAL + uIL-18 + uHGF + uNGAL/MMP-90.73 (0.62 to 0.84)0.06
Day 14
    uHGF0.74 (0.53 to 0.94)NA
    uHGF + uNGAL0.76 (0.57 to 0.96)0.53
    uHGF + uNGAL + uIL-180.81 (0.63 to 0.99)0.37
    uHGF + uNGAL + uIL-18 + uCystatin C0.80 (0.62 to 0.98)0.61
    uHGF + uNGAL + uIL-18 + uCystatin C + uNGAL/MMP-90.88 (0.74 to 1.01)0.44
Largest relative changea
    uHGF0.74 (0.60 to 0.89)NA
    uHGF + uNGAL0.84 (0.73 to 0.94)0.22
    uHGF + uNGAL + uCystatin C0.83 (0.73 to 0.94)0.22
    uHGF + uNGAL + uCystatin C + uNGAL/MMP-90.83 (0.73 to 0.94)0.22
    uHGF + uNGAL + uCystatin C + uNGAL/MMP-9 + uIL-180.84 (0.73 to 0.94)0.09
  • AUC, area under the receiver-operating characteristic curve; CI, confidence interval; uCystatin C, urinary cystatin C; NA, not applicable; uNGAL, urinary neutrophil gelatinase-associated lipocalin; uHGF, urinary hepatocyte growth factor.

  • a Largest relative change in the first 14 days as compared with day 1.

  • b Compared with uCystatin C on day1, uHGF on day 14, and uHGF in largest relative change.