Table 4.

Summary of individual pharmacokinetic estimates in dialysis patients and HV

Dialysis Patients (Mean ± SD)HV (Mean ± SD)
Thiosulfate generation (nmol/min per kg)14.6 ± 6.110.8 ± 3.6
Renal clearance (ml/min per kg body wt)1.86 ± 0.45
Hemodialysis clearance (ml/min per kg body wt)2.49 ± 1.3
Nonrenal clearance (ml/min per kg body wt)2.04 ± 0.722.25 ± 0.42
Total body clearance (ml/min per kg body wt)Off-dialysis: 2.04 ± 0.724.11 ± 0.77
On-dialysis: 4.53 ± 1.4
Bioavailability (%)7.6 (0.8 to 26)
  • Values represent the mean (± SD) or the median with range. HV, Healthy volunteers.