Table 3.

Pharmacokinetic parameters in dialysis patients after 8 g (32,350 μmol) of intravenous STS off-hemodialysis and on-hemodialysis

Patient (ID)Off-HemodialysisOn-Hemodialysis
AUC0→μ (μmol·min/L)Total Body Clearance (ml/min per kg body wt)AUC0→μ (μmol·min/L)Total Body Clearance (ml/min per kg body wt)Estimated Hemodialysis Clearancea (ml/min per kg body wt)
1261,7531.3487,4214.012.67
2336,6911.11114,5643.252.14
3197,0002.39110,9254.251.86
4156,3602.5649,6298.055.5
5253,6182.28129,5454.452.17
6212,0273.17120,4895.562.4
7154,5212.47108,3583.511.04
8163,8672.33109,3943.51.17
9338,1500.9295,3684.03.1
10236,1591.8592,5504.712.86
231,015 ± 67,9692.04 ± 0.72101,824 ± 22,4144.53 ± 1.402.49 ± 1.3
  • Mean (±SD) values of all parameters are given at the end of the table.

  • a Estimated hemodialysis clearance = total body clearance on-hemodialysis − total body clearance off-hemodialysis.