Table 2.

Characteristics and pharmacokinetic parameters in healthy volunteers (HV) after 8 g of intravenous STS (32,250 μmol)

HV (ID)Age (yr)Gender (f/m)Body Weight (kg)AUC0→μ (μmol·min/L)24-Hour Urinary TS Excretion after iv STS (μmol/24 h)Total Body Clearance (ml/min per kg body wt)Renal Clearance (ml/min per kg body wt)Nonrenal Clearance (ml/min per kg body wt)
1164m7410,557312,6204.132.082.05
1239m6685,90113,7605.602.413.2
1357f65133,77315,6703.711.821.9
1448f8081,95314,8404.922.282.64
1563f7898,14514,9104.211.992.22
1660f74109,29314,2603.991.822.17
1745f56144,31315,3103.991.992
1854f69136,55313,8503.421.481.94
1959f53202,48696003.000.912.06
57 (39 to 64)7/268 ± 9.4121,999 ± 3747313,869 ± 18474.11 ± 0.771.86 ± 0.452.25 ± 0.42
  • Mean (±SD) or median (range) values of all parameters are given at the end of the table. AUC, area under the curve; TS, thiosulfate; STS, sodium thiosulfate.