Table 2.

GFR estimating equations in childrena

GFR Estimating EquationnAgebGFRcCreatinine/Cystatin C Assay AnalyzerGFR Measurement Method
Serum creatinine based
    bedside CKiD (23)41.3 [height/creatinine]3491 to 1641.3 (16 to 93)Enzymatic [Advia 2400]Iohexol
    Counahan et al. (24)43 [height/creatinine]1082 to 14d4 to 200Modified Jaffée [Technicon]51Cr-EDTA
    Leger et al. (25)0.641 [weight/creatinine] + 16.063 [(height)2/creatinine]970.8 to 21100 (31 to 200)Kinetic Jaffé [Hitachi 911]51Cr-EDTA
    Schwartz et al. (26, 27)[55 × height]/creatinine; and [70 × height]/creatinine if boy ≥13 years1860.5 to 20125 (0 to 220)Modified Jaffé [Technicon]Inulin/creatinine clearance
Serum cystatin C based
    Filler et al. (28)91.62 [1/cystatin C]1.1235361 to 18103 (7 to 209)Particle-enhanced nephelometric immunoassay (PENIA) [Behring BN ProSpec]99mTc-DTPA
    Grubb et al. (29)84.69 [1/cystatin C]1.680; and 84.69 [1/cystatin C]1.680 × 1.384 if age <14 years536f0.3 to 9363 (11 to 124)g; and 113 (37 to 240)hParticle-enhanced turbidimetric immunoassay (PETIA) [Hitachi Modular P]Iohexol
Serum creatinine and cystatin C based
    Bouvet et al. (30)63.2 [1.2/cystatin C]0.56 × [1.09/creatinine]0.35 × [weight/45]0.3 × [age/14]0.41001.4 to 22.895 (18 to 200)Kinetic Jaffé (Olympus analyzer)/PENIA [BN-ProSpec]51Cr-EDTA
    CKiD (23)39.1 [height/creatinine]0.516 × [1.8/cystatin C]0.294 × [30/BUN]0.169 × 1.099male × [height/1.4]0.1883491 to 1641.3 (16 to 93)Enzymatic [Advia 2400]/PETIA [DAKO]Iohexol
    Zappitelli et al. (31)43.82 [1/cystatin C]0.635 × [1/creatinine]0.547 × 1.35height1032 to 1874 ± 36Enzymatic [Vitros; Ortho-Clinical Diagnostics]/PENIA [Behring Nephelometer System]Iothalamate
  • BUN, blood urea nitrogen; 51Cr-EDTA, 51-cromium edetic acid; 99mTc-DTPA, 99mTc-diethylene-triamine-pentaacetic acid; CKiD, Chronic Kidney Disease in Children.

  • a Height, m; weight, kg; creatinine, mg/dl; cystatin C, mg/L; BUN, mg/dl.

  • b Age range, years.

  • c GFR, ml/min per 1.73 m2 except Leger's and Bouvet's in ml/min: mean (range) presented for bedside CKiD, Leger, Filler, Bouvet, and CKiD; range presented for Counahan; median (range) presented for Schwartz; median (2.5th and 97.5th percentiles) presented for Grubb; mean ± SD presented for Zappitelli.

  • d 103 children and 5 adults.

  • e Plasma creatinine value corrected to account for noncreatinine chromogens.

  • f n = 85 for 0.3 to 17 year old category.

  • g ≥18 years old.

  • h 0.3 to 13 years old.