Table 2.

Adjusted rates of clinical outcomes per 1000 person-years by level of eGFR and proteinuria measured by dipstick

eGFR (ml/min per 1.73 m2)OutcomePVDPCI or CABGCHFCVA/TIA
Normal ProteinuriaMild ProteinuriaHeavy ProteinuriaOverallNormal ProteinuriaMild ProteinuriaHeavy ProteinuriaOverallNormal ProteinuriaMild ProteinuriaHeavy ProteinuriaOverallNormal ProteinuriaMild ProteinuriaHeavy ProteinuriaOverall
≥60Events (n)973159211153474558713154631253404136179323133741052792
People in cell (n)754,15858,4008013820,571754,15858,4008013820,571754,15858,4008013820,571754,158584,008013820,571
Adjusted rate0.220.330.260.231.31.61.91.40.220.520.830.250.580.861.40.61
95% CI0.21 to 0.250.27 to 0.390.17 to 0.410.21 to 0.251.3 to 1.41.4 to 1.71.6 to 2.31.3 to 1.40.20 to 0.240.46 to 0.590.69 to 1.000.23 to 0.270.55 to 0.620.77 to 0.961.2 to 1.80.58 to 0.64
45 to 59.9Events (n)366772546811161916713748412661301237933211751219
People in cell (n)68,7688783229479,84568,7688783229479,84568,7688783229479,84568,7688783229479,845
Adjusted rate0.260.290.390.271.41.41.71.40.320.490.940.340.680.881.30.7
95% CI0.23 to 0.310.23 to 0.380.26 to 0.590.23 to 0.311.3 to 1.51.2 to 1.61.3 to 2.21.3 to 1.50.29 to 0.360.42 to 0.580.78 to 1.150.30 to 0.370.62 to 0.740.76 to 1.041.1 to 1.70.64 to 0.76
30 to 44.9Events (n)1325022204254885239450720215286133113977547
People in cell (n)11,8233296159416,71311,8233296159416,71311,8233296159416,71311,8233296159416,713
Adjusted rate0.280.330.370.291.31.41.71.30.440.531.000.440.731.081.50.82
95% CI0.22 to 0.340.25 to 0.450.24 to 0.580.24 to 0.351.1 to 1.41.1 to 1.71.3 to 2.21.2 to 1.50.39 to 0.510.45 to 0.630.83 to 1.210.39 to 0.500.64 to 0.830.89 to 1.311.2 to 1.90.72 to 0.92
15 to 29.9Events (n)212124662716357818010985374603737134
People in cell (n)180110789773856180110789773856180110789773856180110789773856
Adjusted rate0.240.410.660.360.90.92.21.20.640.830.860.610.831.011.50.9
95% CI0.15 to 0.380.26 to 0.640.43 to 1.020.26 to 0.480.6 to 1.30.5 to 1.41.6 to 3.20.9 to 1.50.53 to 0.770.66 to 1.030.67 to 1.100.52 to 0.710.63 to 1.080.72 to 1.421.0 to 2.10.74 to 1.10
  • Adjusted for age; gender; diabetes; hypertension; socioeconomic status; and history of cancer, cerebrovascular disease, CHF, chronic pulmonary disease, dementia, diabetes with end-organ damage, diabetes without chronic complication, AIDS/HIV, metastatic solid tumor, myocardial infarction, mild liver disease, moderate or severe liver disease, paralysis, peptic ulcer disease, PVD, renal disease, or rheumatic disease. In this analysis, dipstick urinalysis was used to classify participants with respect to proteinuria as normal (urine dipstick negative), mild (urine dipstick trace or 1+), or heavy (urine dipstick ≥2+). Adjusted rate is given per 1000 patient-years. n = 920,985. The tests for linear trend across proteinuria categories were all significant at the P < 0.001 level. Tests for trend across eGFR categories were PVD, P = 0.01; PCI or CABG, P = 0.81; CHF, P < 0.001; and CVA/TIA, P < 0.001. CI, confidence interval; PCI, percutaneous coronary intervention; CABG, coronary artery bypass grafting; CVA, cerebrovascular accident; TIA, transient ischemic attack.