Table 3.

Association of CKD with CVD based on serum creatinine and cystatin C estimates

eGFR (ml/min per 1.73 m2)CKD-EpiCystatin C Three-variable EquationCystatin C One-variable Equation
n (%)Unadjusted Odds Ratio (95% CI)Adjusted Odds Ratio (95% CI)an (%)Unadjusted Odds Ratio (95% CI)Adjusted Odds Ratio (95% CI)an (%)Unadjusted Odds Ratio (95% CI)Adjusted Odds Ratio (95% CI)a
Piecewise linear analysis
    >60b501 (49)1.06 (0.89, 1.26)1.07 (0.88, 1.29)554 (54)0.98 (0.88, 1.11)0.98 (0.86, 1.11)689 (67)1.05 (0.96, 1.15)1.03 (0.93, 1.14)
    <60b527 (51)1.35 (1.18, 1.55)1.31 (1.12, 1.53)474 (46)1.53 (1.33, 1.77)1.48 (1.25, 1.75)339 (33)1.55 (1.31, 1.83)1.49 (1.23, 1.81)
CKD 3 groups
    >60501 (49)1.00 (ref)1.00 (ref)554 (54)1.00 (ref)1.00 (ref)689 (67)1.00 (ref)1.00 (ref)
    30 to 59477 (46)1.45 (1.11, 1.88)1.40 (1.04, 1.87)433 (42)1.63 (1.26, 2.12)1.54 (1.15, 2.07)312 (30)2.12 (1.61, 2.78)2.00 (1.47, 2.72)
    <3050 (5)4.79 (2.55, 9.03)4.16 (2.03, 8.49)41 (4.0)6.60 (3.17, 13.76)5.68 (2.42,13.34)27 (3)5.03 (2.17, 11.67)4.25 (1.58, 1.46)
CKD 2 groups
    >60501 (49)1.00 (ref)1.00 (ref)554 (54)1.00 (ref)1.00 (ref)689 (67)1.00 (ref)1.00 (ref)
    <60527 (51)1.62 (1.25, 2.08)1.53 (1.15, 2.03)474 (46)1.83 (1.42, 2.36)1.67 (1.25, 2.23)339 (33)2.26 (1.73, 2.95)2.09 (1.55, 2.83)
  • ref, referent group.

  • a Adjusted for age, gender, race, body mass index, smoking, diabetes, hypertension, systolic blood pressure, low density lipoprotein cholesterol, high density lipoprotein cholesterol, vitamin D, and log C-reactive protein. The sample sizes are based on the complete case data for all variables used in the multivariable models.

  • b Values per 10 ml/min per 1.73 m2 lower eGFR.