Table 5.

Sensitivity analyses of RFFT score with albuminuria in the youngest age tertile

Albuminuria (mg/24 h)B95% CIP
General population samplea
    low (<10)ReferenceReferenceReference
    intermediate (10 to 29)−1.4−6.2 to 3.30.55
    elevated (≥30)−10.6−19.9 to −1.30.02
Measurements of kidney function
    eGFR CKD-EPI
        low (<10)ReferenceReferenceReference
        intermediate (10 to 29)−2.08−4.8 to 0.60.13
        elevated (≥30)−5.23−10.4 to −0.040.04
    creatinine clearance (24-hour urine collection)
        low (<10)ReferenceReferenceReference
        intermediate (10 to 29)−2.26−4.9 to 0.40.10
        elevated (≥30)−5.26−10.5 to −0.050.04
    Cockroft–Gault formula
        low (<10)ReferenceReferenceReference
        intermediate (10 to 29)−2.45−5.1 to 0.30.75
        elevated (≥30)−5.27−10.4 to −0.090.04
Exclusion of comorbidities
    after exclusion of diabetes mellitus
        low (<10)ReferenceReferenceReference
        intermediate (10 to 29)−1.92−4.6 to 0.80.13
        elevated (≥30)−6.04−11.3 to −0.70.03
    after exclusion of eGFR<60 ml/min per 1.73 m2
        low (<10)ReferenceReferenceReference
        intermediate (10 to 29)−2.18−4.9 to 0.50.15
        elevated (≥30)−5.77−11.1 to −0.40.03
    after exclusion of cardiovascular disease
        low (<10)ReferenceReferenceReference
        intermediate (10 to 29)−2.14−4.8 to 0.60.57
        elevated (≥30)−5.62−10.9 to −0.30.04
    after exclusion of cerebrovascular disease
        low (<10)ReferenceReferenceReference
        intermediate (10 to 29)−2.16−4.9 to 0.50.13
        elevated (≥30)−5.13−10.3 to −0.060.05
  • Model adjusted for adjusted for classes of albuminuria, eGFR, age, gender, educational level, diabetes, hypertension, history of cardiovascular disease, body mass index, alcohol use, cholesterol, and smoking. In the sensitivity analyses, no significant associations were found in the two older tertiles of age CKD-EPI, Chronic Kidney Disease-Epidemiology Collaboration.

  • a Subsample PREVEND cohort reflecting the prevalence of elevated albuminuria in the normal population (7.5%).