Table 3.

Vascular risk factors and renal variables dependent on clinical classes of albuminuria and eGFR

Albuminuria (mg/24 h)eGFR (ml/min per 1.73 m2)
Low (<10)Intermediate (10 to 29)Elevated (≥30)PaLow (<60)Intermediate (60 to 89)Normal (≥90)Pb
n220312965963442925826
Age (years), mean ± SD52 ± 1155 ± 1261 ± 12<0.00165 ± 1155 ± 1150 ± 10<0.001
Men (%)1010 (46)720 (56)410 (69)<0.001155 (45)1441 (49)544 (66)<0.001
Cardiovascular risk factors
    history of vascular events (%)117 (5)91 (7)100 (17)<0.00154 (16)213 (7)40 (5)<0.001
    diabetes mellitus (%)68 (3)88 (7)99 (17)<0.00149 (14)162 (6)44 (5)<0.001
    hypertension (%)500 (23)506 (39)383 (64)<0.001226 (66)946 (32)217 (26)<0.001
    systolic BP (mmHg), mean ± SD121 ± 15129 ± 17138 ± 21<0.001134 ± 21125 ± 18124 ± 16<0.001
    diastolic BP (mmHg), mean ± SD71 ± 875 ± 977 ± 9<0.00175 ± 1073 ± 972 ± 8<0.001
    body mass index (kg/m2), mean ± SD26 ± 427 ± 528 ± 5<0.00128 ± 527 ± 426 ± 5<0.001
    overweight (%)1228 (56)874 (67)446 (75)<0.001259 (75)1838 (63)451 (55)<0.001
    current smoking (%)502 (23)311 (24)159 (27)0.1372 (21)632 (22)268 (33)<0.001
    HDL cholesterol (mmol/L), mean ± SD1.5 ± 0.41.4 ± 0.41.3 ± 0.4<0.0011.4 ± 0.41.4 ± 0.41.4 ± 0.4<0.001
    non–HDL cholesterol (mmol/L), mean ± SD5.4 ± 1.05.3 ± 1.05.2 ± 1.10.0025.3 ± 1.25.4 ± 1.15.2 ± 1.0<0.001
Renal variables
    eGFR MDRD (ml/min per 1.73 m2), mean ± SD79 ± 1380 ± 1574 ± 18<0.00152 ± 876 ± 899 ± 7<0.001
    UAE (mg/24 h), median [IQR]7 [6 to 8]14 [12 to 20]64 [40 to 136]<0.00114 [7 to 47]9 [6 to 16]10 [7 to 16]<0.001
  • a P value for comparison between normal versus elevated albuminuria; P value for comparison between eGFR categories.