Table 4.

Incidence rate of leukocyte spike events by presence or absence of CKD

EventAnnual Incidence Rate
Non-CKD (95% CI)CKD (95% CI)Unadjusted IRR (95% CI)P for IRRAdjusted IRR (95% CI)P for IRR
Total leukocyte count increase > 11.5 K/μl1.09 (0.93, 1.26)1.95 (1.78, 2.12)1.78 (1.50, 2.11)<0.0011.98 (1.63, 2.41)<0.001
Absolute granulocyte count increase > 8.6 K/μl0.81 (0.68, 0.95)1.43 (1.28, 1.58)1.76 (1.44, 2.14)<0.0012.08 (1.66, 2.62)<0.001
Absolute eosinophil count increase > 0.45 K/μl0.56 (0.45, 0.68)1.80 (1.63, 1.96)3.19 (2.55, 4.00)<0.0012.29 (1.79, 2.94)<0.001
Granulocyte (%) increase > 70%2.25 (2.02, 2.48)6.03 (5.73, 6.34)2.68 (2.39, 3.00)<0.0012.60 (2.29, 2.96)<0.001
Lymphocyte (%) decrease < 18%2.90 (2.64, 3.16)8.44 (8.08, 8.80)2.91 (2.64, 3.22)<0.0012.82 (2.53, 3.15)<0.001
Monocyte (%) increase > 11%2.09 (1.86, 2.31)5.86 (5.56, 6.16)2.81 (2.50, 3.16)<0.0012.68 (2.35, 3.06)<0.001
Eosinophil (%) increase > 3%1.14 (0.98, 1.31)3.12 (2.90, 3.34)2.73 (2.32, 3.20)<0.0012.08 (1.74, 2.49)<0.001
Basophil (%) increase > 2%0.54 (0.43, 0.65)1.31 (1.17, 1.45)2.43 (1.92, 3.08)<0.0012.07 (1.58, 2.71)<0.001
  • Multivariate adjusted for age, gender, race, diabetes, smoking, ACEI or ARB use, statin use, and BP medication use. IRR, incidence rate ratio.