Table 4.

Effect of short daily hemodialysis on components of the MOS sleep survey

Sleep ScaleBaselineMonth 4Month 12Global P
Sleep problems index 1
    per-protocol cohort39 (35, 43)33 (29, 37)33 (29, 36)0.001
    ITT cohort43 (40, 46)37 (34, 40)38 (35, 41)<0.0001
Sleep problems index 2
    per-protocol cohort41 (37, 45)35 (31, 39)34 (31, 38)<0.001
    ITT cohort45 (42, 48)39 (36, 42)39 (36, 42)<0.0001
Sleep adequacy
    per-protocol cohort49 (44, 54)52 (47, 57)53 (49, 58)0.23
    ITT cohort44 (41, 48)50 (46, 54)49 (46, 53)0.007
Sleep disturbances
    per-protocol cohort43 (38, 48)38 (33, 43)36 (30, 41)0.004
    ITT cohort47 (43, 51)42 (37, 46)40 (36, 44)<0.0001
Snoring
    per-protocol cohort44 (37, 51)39 (32, 46)37 (30, 44)0.08
    ITT cohort46 (41, 51)44 (39, 49)44 (38, 49)0.4
Awaken short of breath or with a headache
    per-protocol cohort17 (12, 21)9 (5, 13)12 (8, 16)0.002
    ITT cohort18 (14, 21)12 (9, 15)14 (11, 17)<0.001
Daytime somnolence
    per-protocol cohort39 (35, 43)30 (26, 34)32 (27, 36)0.0001
    ITT cohort44 (41, 47)38 (35, 42)39 (35, 43)<0.0001
Sleep quantity (hours)
    per-protocol cohort6.5 (6.2, 6.9)6.6 (6.3, 6.9)6.6 (6.2, 7.0)0.9
    ITT cohort6.3 (6.0, 6.6)6.5 (6.2, 6.7)6.4 (6.2, 6.7)0.3
Optimal sleep (%)
    per-protocol cohort42 (34, 52)37 (29, 47)38 (29, 48)0.7
    ITT cohort37 (30, 44)35 (28, 43)35 (28, 42)0.9
  • The data are presented as adjusted means (95% confidence interval). The adjustment variables include use of anxiolytics and hypnotics, baseline presence of RLS, time, and interaction of time and use of medications. The per-protocol analysis includes 127 participants, and the ITT analysis includes 235 participants. The global P values are based on testing time (baseline, month 4, and month 12) as a fixed effect from repeated measures analysis of covariance. P ≤ 0.05 for pair-wise comparisons of baseline versus month 4 and month 12 for individual components of the MOS sleep survey (both per-protocol and ITT cohort), with the exception of the snoring scale, sleep quantity, and optimal sleep comparisons of baseline versus month 4 and month 12.