Table 3.

Predictors of the composite end point, progression to ESRD, and all-cause mortality

VariableComposite End PointProgression to ESRDAll-Cause Mortality
HR95% CIPHR95% CIPHR95% CIP
Demographics
    age (per 1 year)1.011.00 to 1.020.0030.990.98 to 1.000.191.091.06 to 1.11<0.001
    men versus women1.401.06 to 1.830.011.360.96 to 1.910.071.851.15 to 2.990.01
Clinical variables
    diabetes1.200.93 to 1.550.151.310.94 to 1.840.101.410.93 to 2.140.10
    hypertension1.860.67 to 5.150.221.940.58 to 6.440.273.150.42 to 23.50.26
    COPD1.100.73 to 1.640.630.880.46 to 1.660.690.910.49 to 1.710.97
    CVD0.910.68 to 1.210.810.960.64 to 1.430.851.160.74 to 1.820.50
Laboratory variables
    serum phosphate (mg/dl)
    P < 3.30.780.51 to 1.190.250.610.30 to 1.240.170.740.43 to 1.280.29
    P ≤ 3.3 and < 3.8RefRefRefRefRefRefRefRefRef
    P ≥ 3.8 and < 4.30.930.66 to 1.330.721.360.84 to 2.180.200.640.36 −1.140.13
    P ≥ 4.32.041.44 to 2.90<0.0012.881.77 to 4.67<0.0012.491.44 to 4.320.001
    eGFR (ml/min)0.940.91 to 0.97<0.0010.880.86 to 0.91<0.0010.970.95 to 0.990.02
    hemoglobin (>12.4 g/dl)0.720.55 to 0.940.010.760.53 to 1.100.150.750.50 to 1.120.16
    calcium (mg/dl)0.880.74 to 1.040.150.750.61 to 0.920.0051.010.78 to 1.310.90
    total cholesterol (mg/dl)0.990.99 to 1.000.400.990.99 to 1.000.301.000.99 to 1.000.99
    uric acid (mg/dl)1.010.99 to 1.020.361.000.93 to 1.080.861.000.99 to 1.020.16
Concomitant medications
    ACE inhibitor use1.010.78 to 1.290.930.850.60 to 1.180.341.180.80 to 1.750.31
    ARBs use1.361.03 to 1.780.021.340.95 to −1.900.091.240.88 to 2.090.16
    vitamin D use1.110.81 to 1.500.491.390.96 to 2.030.081.390.83 to 2.930.20
    calcium salts use1.361.03 to 1.810.021.170.82 to 1.660.371.260.77 to 2.050.33
  • ARB, Angiotensin Receptor Blockers.