Table 3.

Cut-off thresholds that achieve at least 80% specificity for predicting bone histomorphometric abnormalities with corresponding Sens., PPV, and NPV

AssayBone ParameterLowHigh
Cut-offSens.PPVNPVCut-offSens.PPVNPV
Sclerostin (pg/ml)Ac.f.27840.330.670.5323870.440.900.35
BFR/BS28000.350.570.6619250.590.930.40
NOb/BPm30360.330.080.9615880.620.970.32
BV/TV28490.290.570.5730580.190.640.39
iPTH (pg/ml)Ac.f.3560.390.600.643820.420.410.81
BFR/BS3350.400.720.533910.430.380.84
NOb/BPm1630.620.970.233350.740.440.94
BV/TV3350.350.750.444340.260.330.76
  • Sens., sensitivity; PPV, positive predictive value; NPV, negative predictive value.