Table 5.

Histologic comparison of early C4d+ biopsies with and without TMA

TMA+TMA−P
n721
Glomeruli
    total glomeruli (mean)2421
    thrombi1000<0.0001
    mesangiolysis42.800.01
    double contours42.800.01
    neutrophilic glomerulitisa10014.30.0001
    acute transplant glomerulitis57.147.60.99
    global glomerulosclerosis71.423.80.06
    segmental glomerulosclerosis04.8
    ischemic glomerulopathy85.723.80.007
Peritubular capillaries
    peritubular capillaritis - neutrophilsb10023.80.007
    peritubular capillaritis - mononuclear57.152.41
Arterioles
    obliterative arteriolopathy57.100.002
    arteriolar thrombi42.800.01
    arteriolar hyalinosis42.847.61
Arteries
    endothelialitis57.123.80.16
    arterial intimal fibrosis42.847.61
Tubules and interstitium
    ATN10076.20.29
    interstitial mononuclear cells85.771.40.64
    tubulitis42.828.60.65
    interstitial hemorrhage42.828.60.65
    interstitial fibrosis57.114.30.04
    tubular atrophy11.814.30.57
  • The values are the percentages of biopsies with lesions in each group. ATN, acute tubular necrosis.

  • a Proportion of biopsies with more than two neutrophils in the worst affected glomeruli.

  • b Proportion of biopsies with more than two neutrophils in more than 10% of the PTC.