Table 3.

Solute clearances in normal subjects

% Protein Bound[Plasma] (mg/dl)K (ml/min per 1.73 m2)Kbs/Ku
Urea14 ± 357 ± 7
PCS97 ± 10.43 ± 0.1319 ± 4a0.34 ± 0.08
IS96 ± 1b0.11 ± 0.0828 ± 10a,b0.52 ± 0.24
HIPP64 ± 5b,c0.22 ± 0.22270 ± 126a,b,c5.1 ± 3.0b,c
  • Values for % protein binding could be measured only after addition of exogenous solute to the normal plasma samples as described in the methods. [Plasma], concentration in plasma; K, urinary clearance; Kbs/Ku, ratio of the urinary clearance of bound solute to the urinary clearance of urea.

  • a P < 0.05 versus urea.

  • b P < 0.05 versus PCS.

  • c P < 0.05 versus IS.