Table 1.

Characteristics of CRIC participants, stratified by baseline eGFR (in ml/min per 1.73 m2)

eGFR <30 (n = 665)eGFR 30 to <45 (n = 1326)eGFR 45 to <60 (n = 1200)eGFR ≥60 (n = 400)P
Demographic characteristics
    age (years)58.6 (11.3)59.7 (10.7)58.6 (10.4)51.5 (11.0)<0.01
    male311 (46.8%)703 (53%)709 (59.1%)228 (57%)<0.01
    non-white341 (51.3%)661 (49.8%)597 (49.8%)230 (57.5%)0.2
    Hispanic54 (8.1%)57 (4.3%)39 (3.3%)18 (4.5%)<0.01
    education<0.01
        less than high school152 (22.9%)262 (19.8%)152 (12.7%)32 (8.0%)
        high school graduate143 (21.5%)279 (21.0%)200 (16.7%)70 (17.5%)
        some college197 (29.6%)395 (29.8%)369 (30.8%)139 (34.8%)
        college graduate173 (26.0%)390 (29.4%)479 (39.9%)158 (39.6%)
Prevalent conditions
    diabetes349 (20.9%)691 (41.4%)500 (29.9%)131 (7.8%)<0.01
    hypertension612 (92.0%)1201 (90.6%)996 (83.1%)268 (67.2%)<0.01
    history of elevated cholesterol583 (87.7%)1114 (84%)957 (79.8%)271 (67.8%)<0.01
    smoking (ever vs. never)405 (60.9%)758 (57.2%)655 (54.6%)191 (47.8%)<0.01
    stroke78 (11.7%)147 (11.1%)120 (10.0%)18 (4.5%)<0.01
    coronary heart disease169 (25.4%)324 (24.4%)257 (21.4%)52 (13.0%)<0.01
    peripheral arterial disease74 (11.1%)103 (7.8%)60 (5.0%)11 (2.8%)<0.01
Anthropometric and laboratory measures
    eGFR (ml/min per 1.73 m2)25.0 (3.4)37.9 (4.2)51.7 (4.2)67.7 (7.6)
    systolic blood pressure (mmHg)130.5 (23.6)129.0 (22.5)126.0 (20.6)123.5 (20.0)<0.01
    diastolic blood pressure (mmHg)69.9 (13.3)70.8 (12.7)71.7 (12.5)74.8 (12.8)<0.01
    total cholesterol (mg/dl)183.4 (51.7)182.9 (44.7)183.0 (41.8)183.52 (39.2)0.9
    hemoglobin (g/dl)11.9 (1.7)12.5 (1.7)13.1 (1.7)13.4 (1.6)<0.01
    serum albumin (g/dl)3.9 (0.5)3.9 (0.5)4.0 (0.4)4.1 (0.4)<0.01
    log C-reactive protein1.1 (1.3)1.1 (1.3)0.9 (1.2)0.6 (1.2)<0.01
    total homocysteine (μmol/L)19.0 (6.9)15.9 (5.8)13.3 (5.0)10.9 (4.0)<0.01
    albuminuria (mg/day)<0.01
        <30 mg/day123 (8.7%)450 (31.9%)599 (42.4%)240 (17%)
        30 to 299 mg/day200 (32.2%)364 (28.7%)302 (26.4%)79 (21.4%)
        300 to 999 mg/day121 (19.5%)227 (17.9%)141 (12.3%)30 (8.1%)
        ≥1000 mg/day178 (28.6%)226 (17.8%)101 (8.8%)20 (5.4%)
  • The results are presented as the means (standard deviation) or frequency (N, %).