Table 2.

Cox proportional hazard models on the risk of the composite primary outcome

HR95% CI HRP
FGF-23 (per 10 pg/ml increase)1.091.031.150.003
Estimated creatinine clearance (CG) of <47.6 ml/min per 1.73 m2
    FGF-23 (per 10 pg/ml increase)1.091.001.190.06
Estimated creatinine clearance (CG) of >47.6 ml/min per 1.73 m2
    FGF-23 (per 10 pg/ml increase)1.091.011.160.03
FGF-23 (per 10 pg/ml increase)1.091.031.150.004
    age1.010.961.070.67
FGF-23 (per 10 pg/ml increase)1.081.021.140.01
    sex (male × female)1.770.486.490.39
FGF-23 (per 10 pg/ml increase)1.091.031.160.003
    race (white)1.600.544.750.40
FGF-23 (per 10 pg/ml increase)1.091.031.150.005
    treatment arm (original trial)1.100.383.210.86
FGF-23 (per 10 pg/ml increase)1.091.031.150.01
    estimated creatinine clearance (CG)0.980.941.010.13
FGF-23 (per 10 pg/ml increase)1.081.021.140.01
    24-hour creatinine clearance0.980.951.020.34
FGF-23 (per 10 pg/ml increase)1.081.021.150.01
    24-hour proteinuria1.311.101.570.003
FGF-23 (per 10 pg/ml increase)1.091.031.150.003
    glycated hemoglobin0.980.751.280.89
FGF-23 (per 10 pg/ml increase)1.091.021.160.01
    intact PTH1.011.001.010.16
FGF-23 (per 10 pg/ml increase)1.091.031.150.003
    phosphate1.710.694.240.25
FGF-23 (per 10 pg/ml increase)1.081.021.150.02
    urinary fractional excretion of phosphate1.061.001.110.04
FGF-23 (per 10 pg/ml increase)1.091.021.160.02
    urinary fractional excretion of phosphate1.050.981.110.15
    estimated creatinine clearance (CG)0.990.951.030.62
FGF-23 (per 10 pg/ml increase)1.081.011.150.02
    estimated creatinine clearance (CG)0.970.941.010.13
    24-hour proteinuria1.341.101.630.004
FGF-23 (per 10 pg/ml increase)1.091.011.160.02
    estimated creatinine clearance (CG)0.980.941.020.26
    intact PTH1.000.991.010.55
  • HR, hazard ratio; CG, Cockcroft-Gault.