Table 2.

Indications for initiation of rituximab

IndicationsComplete Remission at Rituximab Initiation (n = 17)Partial Remission at Rituximab Initiation (n = 22)Combined
Persistent symptoms attributable to AAV088
Cyclophosphamide dependence (with or without symptoms)448
Bone marrow toxicity235
Steroid toxicity (e.g., weight gain, diabetes, avascular necrosis, osteoporotic fracture)6511
Rising or persistently high ANCA41014
  • a Other includes severe fatigue (n = 2), patient desire to wean oral immunosuppression (n = 1), and bacterial pneumonia on cyclophosphamide and prednisone (n = 1).