Table 2.

Indications for initiation of rituximab

IndicationsComplete Remission at Rituximab Initiation (n = 17)Partial Remission at Rituximab Initiation (n = 22)Combined
Persistent symptoms attributable to AAV088
Cyclophosphamide dependence (with or without symptoms)448
Bone marrow toxicity235
Steroid toxicity (e.g., weight gain, diabetes, avascular necrosis, osteoporotic fracture)6511
Rising or persistently high ANCA41014
Othera224
  • a Other includes severe fatigue (n = 2), patient desire to wean oral immunosuppression (n = 1), and bacterial pneumonia on cyclophosphamide and prednisone (n = 1).