Table 4.

Effect of allopurinol in UA levels and renal function estimated by MDRD-4

Uric Acida (mg/dl)P1eGFRb (ml/min per 1.73 m2)P2
Control group
    Basal7.3 ± 1.639.5 ± 12.4
    6 months7.0 ± 1.6ns37.2 ± 14.3ns
    12 months7.4 ± 2.0ns35.6 ± 13.4ns
    24 months7.5 ± 1.7ns35.9 ± 12.3ns
Allopurinol group
    Basal7.8 ± 2.140.8 ± 11.2
    6 months6.2 ± 1.50.00041.1 ± 12.9ns
    12 months6.0 ± 1.80.00041.1 ± 13.2ns
    24 months6.0 ± 1.20.00042.2 ± 13.2ns
  • a P = 0.016 between groups.

  • b P = 0.000 between groups.

  • P1, differences in comparison to baseline period within each experimental group.

  • P2, differences in comparison to baseline period within each experimental group.