Table 1.

Characteristics of study subjects and serum/plasma analyte concentrations

Healthy VolunteersHemodialysis Patients
n1222
Age, years38.5 (13.3), 24 to 6167.7 (12.3), 42 to 90a
Women, n811
Weight, kg (study beginning)NA78.2 (16.5), 53.5 to 113.0
Weight, kg (study end)NA78.5 (16.3), 54.5 to 113.0
Dialysis adequacy (Kt/V, study beginning)NA1.42 (0.31)
Dialysis adequacy (Kt/V, study end)NA1.44 (0.34)
Cause of renal failure, nNASmall kidneys/unknown etiology (7), GN (4), membranous nephropathy (3), pyelonephritis (2), diabetes mellitus (2), renal vascular disease (2), IgA nephropathy (1) and Wegener's granulomatosis (1)
Duration of ESRD, monthsNA11, 3 to 120b
Calcium concentration, mmol/L2.39 (0.10)2.29 (0.14)
Albumin-adjusted calcium concentration, mmol/L2.36 (0.10)2.42 (0.14)
Phosphate concentration, mmol/L1.11 (0.14)1.54 (0.42)
ALP activity, U/L62 (21)99 (55)
Intact PTH concentration, ng/L51.9 (23.0)303 (274)
Biointact PTH concentration, ng/L27.5 (11.4)131 (109)
Daily dietary intake
Energy, kcal/kg (study beginning)NA21.4 (7.9), 10.0 to 38.0
Energy, kcal/kg (study end)NA20.2 (7.0), 9.0 to 32.0
Protein, g/kg (study beginning)NA0.80, 0.30 to 1.30b
Protein, g/kg (study end)NA0.80, 0.30 to 1.10b
Phosphate, mg (study beginning)NA982 (259), 524 to 1482
Phosphate, mg (study end)NA978 (282), 524 to 1430
Calcium, mg (study beginning)NA723 (201), 337 to 1186
Calcium, mg (study end)NA707 (298), 203 to 1359
  • The mean values were obtained from all of the data for all of the analytes. The mean age was calculated from baseline data. NA, not applicable to the healthy volunteers.

  • a The age of the hemodialysis patients was significantly different (P < 0.05) than that of the healthy volunteers.

  • b Values for continuous variables are expressed as mean (SD), range (where given), or median, range.