Table 2.

Characteristics of ADPKD patients and of age- and gender-matched healthy controls (live kidney donors) per quartile of agea

VariableQuartile 1Quartile2Quartile 3Quartile 4P for Trendc
ADPKDHCADPKDHCADPKDHCADPKDHCADPKDHC
Age (years)27 ± 528 ± 535 ± 236 ± 243 ± 343 ± 354 ± 554 ± 5<0.001<0.001
Male gender, n (%)16 (64)16 (64)16 (55)16 (55)12 (46)12 (46)16 (62)16 (62)0.60.6
BMI (kg/m2)25.1 ± 4.725.2 ± 3.326.4 ± 5.225.4 ± 4.025.1 ± 3.324.8 ± 3.427.4 ± 4.626.9 ± 4.30.20.66
MAP (mmHg)96 ± 1191 ± 1296 ± 7b89 ± 696 ± 1191 ± 797 ± 995 ± 100.90.2
Antihypertensive medicine, n (%)15 (60)b1 (4)23 (79)b0 (0)19 (73)b0 (0)24 (92)b1 (4)0.051.0
ACEI/ARB, n (%)14 (56)b0 (0)19 (73)b0 (0)18 (69)b0 (0)21 (81)b0 (0)0.31.0
TRV (L)1.0 (0.7 to 2.0)1.6 (1.1 to 2.5)1.6 (1.1 to 2.1)1.6 (1.1 to 2.2)0.1
Hb (mmol/L)8.5 ± 0.7b9.0 ± 0.88.3 ± 0.8b9.0 ± 1.08.3 ± 0.88.7 ± 0.98.4 ± 1.0b8.9 ± 0.80.90.04
Serum creatinine (μmol/L)93 ± 46b73 ± 11102 ± 56b74 ± 10107 ± 63b71 ± 11145 ± 92b78 ± 130.040.2
GFR (ml/min)117 ± 32129 ± 17102 ± 30b130 ± 1684 ± 32b122 ± 2474 ± 47b116 ± 18<0.0010.04
ERPF (ml/min)374 ± 119b527 ± 83335 ± 103b491 ± 68287 ± 116b454 ± 88203 ± 104b429 ± 62<0.001<0.001
FF32 ± 4b25 ± 231 ± 4b26 ± 329 ± 4b27 ± 430 ± 4b27 ± 20.10.007
RVR (dynes/cm−2)12 (10 to 16)b8 (7 to 9)14 (11 to 17)b8 (7 to 9)17 (13 to 21)b10 (8 to 12)22 (18 to 33)b10 (9 to 11)<0.001<0.001
  • HC, healthy control.

  • a Parametric variables are expressed as mean ± SD, whereas nonparametric variables are given as median (25th to 75th percentile).

  • b P < 0.05 between ADPKD and healthy controls.

  • c P values obtained using ANOVA/Kruskal–Wallis.