RT Journal Article
SR Electronic
T1 Idiopathic IgA Nephropathy: Pathogenesis, Histopathology, and Therapeutic Options
JF Clinical Journal of the American Society of Nephrology
JO CLIN J AM SOC NEPHROL
FD American Society of Nephrology
SP 1054
OP 1061
DO 10.2215/CJN.04351206
VO 2
IS 5
A1 Tumlin, James A.
A1 Madaio, Michael P.
A1 Hennigar, Randolph
YR 2007
UL http://cjasn.asnjournals.org/content/2/5/1054.abstract
AB IgA nephropathy is one of the most common causes of glomerulonephritis in the world. Proliferative and crescentic forms of IgA are found in up to 30% of cases and are associated with nephrotic-range proteinuria, accelerated hypertension, and accelerated decline toward ESRD. Despite its prevalence and clinical importance, there is no unifying nomenclature or consensus for the treatment of specific histologic subgroups. As a consequence, the development of clinically effective treatment regimens for IgA nephropathy have lagged behind other, less common forms of glomerulonephritis. Herein is reviewed the pathogenesis and histologic subtypes of IgA nephropathy and how conventional and immunosuppressive therapies have an impact on renal survival and recurrence rates. The use of known clinical risk factors for disease progression in conjunction with specific histologic features can be a guide to both induction and consolidation therapies for individual patients with IgA nephropathy.